Fatal PCR-negative herpes simplex virus-1 encephalitis with GABAA receptor antibodies

Herpes simplex virus encephalitis.

Introduction Herpes simplex virus encephalitis is one of the more common sporadic viral encephalitides with an estimated incidence of one case per half million individuals per year (1, 2), but the true incidence may be higher. Untreated it is associated with a mortality rate exceeding 70070 and a high morbidity amongst the survivors with only about 9070 returning to normal neurological function...

Analysis of Herpes Simplex Virus in Suspected Encephalitis, Keratitis and Dermal Infections Using Real- Time PCR

Background & Objectives: Herpes viruses can cause diseases in the clinical range. The virus can cause infection in various body parts, especially eyes and nervous system. The aim of this study was at evaluating  the Real-Time TaqMan probe PCR in diagnosing and monitoring of the patients with suspected HSV infections.Materials & Methods: More than a thousand patients with suspected HSV infection...

N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.

OBJECTIVE To determine the presence and kinetics of antibodies against synaptic proteins in patients with herpes simplex virus encephalitis (HSE). METHODS Retrospective analysis of 44 patients with polymerase chain reaction-proven HSE for the presence of a large panel of onconeuronal and synaptic receptor antibodies. The effect of patients' serum was studied in cultures of primary mouse hippo...

Unilateral Negative Myoclonus Caused by Herpes Simplex Virus Encephalitis

Various neurologic manifestations of herpes simplex virus (HSV) encephalitis have been reported on the literatures. Chorea, ballism, choreoathetosis and myoclonus were reported as movement disorders which might be related with brain lesion by HSV encephalitis, but negative myoclonus (NM) has never been reported before. NM can be characterized as a shock-like involuntary jerky movement caused by...

Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report.